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. 1984;34(3A):359-63.

Effects of a new positive inotropic agent, 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)- quinolinone (OPC-8212) and its solvent sulfolane on isolated heart preparations of the rat, guinea pig, and dog

G Grupp, I L Grupp, G Newman, A Schwartz
  • PMID: 6540089

Effects of a new positive inotropic agent, 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)- quinolinone (OPC-8212) and its solvent sulfolane on isolated heart preparations of the rat, guinea pig, and dog

G Grupp et al. Arzneimittelforschung. 1984.

Abstract

3,4-Dihydro-6-[4-(3,4- dimethoxybenzoyl )-1-piperazinyl]-2(1H)- qu inolinone ( OPC -8212) has positive inotropic effects in guinea pig and dog isolated heart preparations. The rat heart ventricle does not respond to OPC -8212 but the atria do. OPC -8212 produces positive inotropic effects in the rat heart ventricle made hypodynamic by pretreatment with calcium entry blockers. Sulfolane , the solvent of OPC -8212, produced negative inotropic effects in most preparations. In isolated heart preparations of the rat and guinea pig, OPC -8212 produced increased coronary flow; sulfolane had only minor effects.

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