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. 1984;64(2):148-52.
doi: 10.1007/BF00695578.

Ultrastructural study of enriched fractions of "tangles" from human patients with senile dementia of the Alzheimer type

J P Brion, A M Couck, J Flament-Durand

Ultrastructural study of enriched fractions of "tangles" from human patients with senile dementia of the Alzheimer type

J P Brion et al. Acta Neuropathol. 1984.

Abstract

Enriched fractions of "tangles" obtained from cases of Alzheimer's disease have been observed by negative staining and platinum: iridium shadowing, and also after treatment with sodium dodecyl sulfate and urea. Abnormal filaments with a 80-nm periodic constriction exhibited a substructure consisting of six protofilaments. They also showed a periodic right-handed twist. Some fibrils with a 160-nm periodic constriction were made up of four protofilaments. These features are discussed in view of known fibrous protein models, especially neurofilaments.

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References

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