Cis-platinum-induced renal sodium wasting

Abstract

A 10-year-old girl with a malignant ovarian germ cell tumor was treated with cis-platinum-based chemotherapy. During the third and fourth courses of therapy, the patient developed hyponatremia, hypomagnesemia, and hypocalcemia. Renal sodium wasting was documented to be the cause of the hyponatremia. Despite normalization of serum electrolytes, hyponatremia again occurred during a period of stress following cessation of cis-platinum. Prior work has documented that cis-platinum-induced hypomagnesemia is related to renal tubular dysfunction with resulting magnesium wasting. A similar etiology for cis-platinum-induced hyponatremia and renal sodium wasting is proposed.