On the nature and extent of XY pairing at meiotic prophase in man
- PMID: 6542485
- DOI: 10.1159/000132070
On the nature and extent of XY pairing at meiotic prophase in man
Abstract
Evidence is presented that pairing between the human X and Y chromosomes could be more extensive at early pachytene than has previously been supposed and could involve even the entire euchromatic portion of the Y chromosome. Following desynapsis over the major part of the X and Y axes, a small paired segment of Xp and Yp remains into late pachytene. Association between the distal tips of Xq and Yq can also be observed in about one half of the spermatocytes examined. A hypothesis linking meiotic pairing to early replicating sites along the chromosomes is proposed.
Similar articles
-
Phosphorylated extracellular signal-regulated kinase 1/2 is localized to the XY body of meiotic prophase spermatocytes.Biochem Biophys Res Commun. 2006 Aug 11;346(4):1261-6. doi: 10.1016/j.bbrc.2006.06.040. Epub 2006 Jun 16. Biochem Biophys Res Commun. 2006. PMID: 16806079
-
Deficiency of X and Y chromosomal pairing at meiotic prophase in spermatocytes of sterile interspecific hybrids between laboratory mice (Mus domesticus) and Mus spretus.Chromosoma. 1992 Jun;101(8):483-92. doi: 10.1007/BF00352471. Chromosoma. 1992. PMID: 1424992
-
The chromosomes of Micromys minutus (Rodentia, Murinae). II. Pairing pattern of X and Y chromosomes in meiotic prophase.Cytogenet Cell Genet. 1987;45(3-4):121-31. doi: 10.1159/000132443. Cytogenet Cell Genet. 1987. PMID: 3691178
-
XY chromosomal bivalent: nucleolar attraction.Mol Reprod Dev. 2005 Sep;72(1):1-6. doi: 10.1002/mrd.20334. Mol Reprod Dev. 2005. PMID: 15915516 Review.
-
The role of unpaired sex chromosomes in spermatogenic failure.Andrologia. 1992 Jan-Feb;24(1):17-20. doi: 10.1111/j.1439-0272.1992.tb02602.x. Andrologia. 1992. PMID: 1519771 Review.
Cited by
-
The behavior and morphology of the X and Y chromosomes during prophase I in the Sitka deer mouse (Peromyscus sitkensis).Chromosoma. 1986;94(4):235-42. doi: 10.1007/BF00290850. Chromosoma. 1986. PMID: 3792117
-
Extensive DNA sequence homologies between the human Y and the long arm of the X chromosome.EMBO J. 1985 Jul;4(7):1739-43. doi: 10.1002/j.1460-2075.1985.tb03844.x. EMBO J. 1985. PMID: 4029125 Free PMC article.
-
Spermatogenesis in two patients with the fragile X syndrome. II. First meiosis: light and electron microscopy.Hum Genet. 1988 Jul;79(3):231-4. doi: 10.1007/BF00366242. Hum Genet. 1988. PMID: 3402994
-
Prophase pairing in a mosaic 18p-;iso 18q human female foetus studied by surface spreading.Hum Genet. 1986 Mar;72(3):256-9. doi: 10.1007/BF00291890. Hum Genet. 1986. PMID: 3957350
-
Molecular genetics of the human X chromosome.J Med Genet. 1985 Aug;22(4):243-9. doi: 10.1136/jmg.22.4.243. J Med Genet. 1985. PMID: 2995673 Free PMC article. Review.