Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Nov;46(2):265-74.

Effect of copper pretreatment on toxicity and antitumor activity of cis-diamminedichloroplatinum in mice

A Naganuma, M Satoh, N Imura
  • PMID: 6542689

Effect of copper pretreatment on toxicity and antitumor activity of cis-diamminedichloroplatinum in mice

A Naganuma et al. Res Commun Chem Pathol Pharmacol. 1984 Nov.

Abstract

Effect of pretreatment with CuSO4 on toxicity and antitumor activity of cis-diamminedichloroplatinum (Cisplatin; CDDP) in mice were examined. Single subcutaneous administration of copper (CuSO4, 40 mumol/kg) 24 hr prior to injection of a lethal dose of CDDP (35 mumol/kg, sc) showed the most favorable effect among various administration conditions tested and completely prevented the manifestation of lethal toxicity of CDDP. In mice subcutaneously inoculated with Ehrlich tumor cells, the preadministration of copper also depressed the lethal and renal toxicity of CDDP without compromising its antitumor activity.

PubMed Disclaimer

Publication types