Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Mar;308(5955):153-8.
doi: 10.1038/308153a0.

Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins

S M Hedrick, E A Nielsen, J Kavaler, D I Cohen, M M Davis

Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins

S M Hedrick et al. Nature. 1984 Mar.

Abstract

Comparison of the sequence of a cloned T cell-specific cDNA with those of cross-reacting cloned cDNAs isolated from a thymocyte library indicates the presence of variable, constant and joining regions remarkably similar in size and sequence to those encoding immunoglobulin proteins. Together with the evidence for somatic gene rearrangements reported in the accompanying paper, this strongly suggests that the TM86 cDNA clone encodes one chain of the T-cell receptor for antigen.

PubMed Disclaimer

Publication types