PHARM--an interactive graphic program for individual and population pharmacokinetic parameter estimation

Abstract

This paper describes a new computer program PHARM to estimate individual or population pharmacokinetic parameters in nonlinear models. PHARM is an interactive program which uses graphic facilities to display data and results. The structural model can be defined using differential or integrated equations. The user can also define an error model associated with experimental data. The nonlinear mixed effect model is used to estimate the mean population parameters and their interindividual variability. The maximum likelihood and Bayesian criteria are used to estimate simultaneously the error and structural model parameters.