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. 1984 Jun 15;224(4654):1239-41.
doi: 10.1126/science.6547247.

Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase

G Petranyi, N S Ryder, A Stütz

Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase

G Petranyi et al. Science. .

Abstract

A new class of synthetic antifungal agents, the allylamines , has been developed by modification of naftifine , a topical antimycotic. SF 86-327, the most effective of these compounds so far, is highly active in vitro against a wide range of fungi and exceeds clinical standards in the oral and topical treatment of guinea pig dermatophytoses. SF 86-327 is a powerful specific inhibitor of fungal squalene epoxidase, a key enzyme in sterol biosynthesis.

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