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. 1984 Feb-Apr;18(1-2):43-9.
doi: 10.1016/0010-468x(84)90022-9.

ELSMOS--an extended least squares modelling system in FORTRAN IV for mini- or micro-computer implementation

R J Francis

ELSMOS--an extended least squares modelling system in FORTRAN IV for mini- or micro-computer implementation

R J Francis. Comput Programs Biomed. 1984 Feb-Apr.

Abstract

A new program ELSMOS has been developed for curve fitting of pharmacokinetic and pharmacodynamic data. The form is sufficiently general, with user-defined model in a separate FORTRAN subroutine, to permit application in many other areas. The principal features are the use of a user-defined error model for statistically rigorous automatic weighting of data, and the containment of program size to a level that enables mini- or micro-computer implementation.

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