Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Aug;43(4):635-40.
doi: 10.1136/ard.43.4.635.

Chemical changes of human knee joint menisci in various stages of degeneration

J Herwig, E Egner, E Buddecke

Chemical changes of human knee joint menisci in various stages of degeneration

J Herwig et al. Ann Rheum Dis. 1984 Aug.

Abstract

Human knee joint menisci graded according to degenerative alterations were submitted to chemical analysis. Normal menisci contained 72% water, 0.12% DNA, 22% collagen, and 0.8% total glycosaminoglycans with the following glycosaminoglycan distribution pattern: 40% chondroitin 6-sulphate, 10-20% chondroitin 4-sulphate, 20-30% dermatan sulphate, and 15% keratan sulphate. The water content increased with increasing degeneration, whereas the collagen and glycosaminoglycan contents decreased with relative increase of chondroitin 6-sulphate.

PubMed Disclaimer

References

    1. Arthritis Rheum. 1983 Jan;26(1):69-76 - PubMed
    1. Science. 1973 Aug 24;181(4101):751-2 - PubMed
    1. Biochem J. 1956 Feb;62(2):315-23 - PubMed
    1. J Biol Chem. 1968 Apr 10;243(7):1536-42 - PubMed
    1. Hoppe Seylers Z Physiol Chem. 1968 Nov;349(11):1497-506 - PubMed