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. 1984 Oct 11;12(19):7435-53.
doi: 10.1093/nar/12.19.7435.

Synthesis and biophysical studies of short oligodeoxynucleotides with novel modifications: a possible approach to the problem of mixed base oligodeoxynucleotide synthesis

T A Millican, G A Mock, M A Chauncey, T P Patel, M A Eaton, J Gunning, S D Cutbush, S Neidle, J Mann
Free PMC article

Synthesis and biophysical studies of short oligodeoxynucleotides with novel modifications: a possible approach to the problem of mixed base oligodeoxynucleotide synthesis

T A Millican et al. Nucleic Acids Res. .
Free PMC article

Abstract

The syntheses of 1,2-dideoxy-D-ribofuranose and 1,2-dideoxy-1-phenyl-beta-D-ribofuranose are described. Oligodeoxynucleotides containing these analogues have been synthesised and hybridized to their complementary strands. Hypochromicity studies have shown that these duplices are less stable than either the totally complementary duplex or those containing A.C and G.T mismatches.

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