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Comparative Study
. 1984 Fall;4(4):609-17.
doi: 10.1089/jir.1984.4.609.

Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes

E Gren, V Berzin, I Jansone, A Tsimanis, Y Vishnevsky, U Apsalons
Comparative Study

Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes

E Gren et al. J Interferon Res. 1984 Fall.

Abstract

In the cDNA library of virus-induced human leukocytes a novel subtype of IFN-alpha gene has been identified and sequenced, named IFN-alpha-N. A comparison of nucleotide sequences within the genes coding for different subtypes of human leukocyte interferon (IFN-alpha) has revealed the natural hybrid structure of individual alpha-IFNs-H,B,F, and N. Certain regions of the genes for IFN-alpha-H,B,F,N show a homology with one of the two structurally distinct groups of leukocyte interferons--either IFN-alpha-A,D or IFN-alpha-C,C1 utilized as reference standards.

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