Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984;103(4):257-62.
doi: 10.1007/BF00387331.

Effects of 1,25-dihydroxycholecalciferol on fracture healing. Calcium, phosphate, and zinc in callus and serum

O Andreen, S E Larsson

Effects of 1,25-dihydroxycholecalciferol on fracture healing. Calcium, phosphate, and zinc in callus and serum

O Andreen et al. Arch Orthop Trauma Surg (1978). 1984.

Abstract

The incorporation of calcium, phosphate, and zinc into the callus of closed tibial fractures was studied in adult rats fed a standard diet. Low doses (60 ng/kg per day) of 1,25(OH)2D3 5 days a week greatly increased early callus mineralization. This was not related to an increased serum calcium-phosphate molar product but rather to a decreased ratio. The incorporation of zinc into callus seemed to be correlated to the mineralization process but not to the 1,25(OH)2D3 administration as such. The question of a direct, indirect, or a complex role of 1,25(OH)2D3 in bone formation and mineralization is discussed.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Calcif Tissue Res. 1976 Nov 24;22(1):85-98 - PubMed
    1. Am J Physiol. 1980 May;238(5):E494-8 - PubMed
    1. J Trauma. 1978 May;18(5):336-40 - PubMed
    1. Acta Orthop Scand. 1978 Dec;49(6):485-91 - PubMed
    1. Calcif Tissue Int. 1981;33(1):1-4 - PubMed

LinkOut - more resources