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. 1984;30(4):255-62.
doi: 10.1159/000199117.

Effects of peptide YY and neuropeptide Y on gastric emptying in man

J M Allen, M L Fitzpatrick, J C Yeats, K Darcy, T E Adrian, S R Bloom

Effects of peptide YY and neuropeptide Y on gastric emptying in man

J M Allen et al. Digestion. 1984.

Abstract

Neuropeptide Y (NPY) and peptide YY (PYY) are two structurally related peptides. PYY has been identified within endocrine cells and NPY within nerves of the gastrointestinal tract. Infusion of PYY at a low dose at a nominal rate of 2 pmol/kg/min resulted in an increment of 59.2 +/- 7.1 pmol/1 in plasma concentration and a significant delay in gastric emptying of glucose. Infusion of NPY at the same rate produced similar plasma concentrations (52.5 +/- 1.1 pmol/1) and had no significant effect on the rate of gastric emptying.

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