The relationship between brain weight and head circumference from birth to age 18 years

Abstract

A relation between head circumference and brain weight of humans is generally believed to exist, but the literature contains only two studies which exhibit a quantitative aspect of the relation, showing that brain weight is proportional to the cube of the head circumference from birth through age 3.5 years. By assembling data from autopsy records, we have been able to show that this cubic relationship holds through brain maturation at around age 18 years.