[Suppression and therapy of experimental autoimmune uveo-retinitis by injections of retinal extract (author's transl)]

Abstract

The uveo-retinitis induced in guinea-pigs after one injection in the foot-pad of an extract of guinea-pig retina mixed with Freund's complete adjuvant (FCA) was successfully inhibited by a series of injections of the retinal extract. These injections were given after the induction by the antigen + FCA, either before (suppression) or after (treatment) the onset of the ocular symptoms. Injections of the antigenic preparation alone, or mixed with Freund's incomplete adjuvant were effective. Depression of cutaneous delayed hypersensitivty was parallel to the inhibition of the disease. The repeated injections provoqued an increase of antibodies, titrated either with the complement fixation test or by passive cutaneous anaphylaxis. But no correlation appeared between these antibodies and the inhibition of the disease.