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. 1978 Jan-Feb;73(1):126-32.
doi: 10.1007/BF01914660.

Ca2+-uptake and -release phenomena from cardiac mitochondria under normal and ischemic conditions

G G Göring, P G Spieckermann

Ca2+-uptake and -release phenomena from cardiac mitochondria under normal and ischemic conditions

G G Göring et al. Basic Res Cardiol. 1978 Jan-Feb.

Abstract

Guinea-pig and dog heart mitochondria were isolated in a KEA-medium. Ca2+-transport across mitochondrial membranes was measured continuously with an Aminco Dual-Wavelength-Spectrophotometer and murexide as a Ca2+-sensitive indicator. Ischemia was produced by cardioplegia at 15 degrees C according to Bretschneider. Guinea-pig heart mitochondria as well as mitochondria from dog heart show a spontaneous Ca2+-release without nonphysiological influence. Addition of 3.5 M Na+ can induce a very quick release of Ca2+ taken up by heart mitochondria. This release is different from that occurring spontaneously. Progressive ischemia results in a marked depression of Ca2+-uptake and spontaneous Ca2+-release.

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References

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