The precise and entire antigenic structure of native lysozyme
- PMID: 656054
- PMCID: PMC1183972
- DOI: 10.1042/bj1710429
The precise and entire antigenic structure of native lysozyme
Abstract
The exact boundary, residue, conformational and directional definitions of the three antigenic sites of native hen's egg-white lysozyme are described. The results clearly reveal that the three antigenic sites account quantitatively for the total antigenic reactivity of the protein. Thus the entire antigenic structure of lysozyme has now been precisely determined and is briefly discussed here, together with the power of the surface-stimulation synthetic concept.
Similar articles
-
Boundary refinement of the lysozyme antigenic site around the disulphide bond 6-127 (site 1) by 'surface-simulation' synthesis.Biochem J. 1978 May 1;171(2):419-27. doi: 10.1042/bj1710419. Biochem J. 1978. PMID: 656053 Free PMC article.
-
The precise and entire antigenic structure of lysozyme: implications of surface-simulation synthesis and the molecular features of protein antigenic sites.Adv Exp Med Biol. 1978;98:41-99. doi: 10.1007/978-1-4615-8858-0_4. Adv Exp Med Biol. 1978. PMID: 82389
-
Enzymic and immunochemical properties of lysozyme. Accurate definition of the antigenic site around the disulphide bridge 30-115 (site 3) by 'surface-simulation' synthesis.Biochem J. 1977 Dec 1;167(3):571-81. doi: 10.1042/bj1670571. Biochem J. 1977. PMID: 603622 Free PMC article.
-
Determination of the entire antigenic structure of native lysozyme by surface-simulation synthesis, a novel concept in molecular recognition.CRC Crit Rev Biochem. 1979;6(4):371-400. doi: 10.3109/10409237909105426. CRC Crit Rev Biochem. 1979. PMID: 88298 Review. No abstract available.
-
Antigenic structures of proteins. Their determination has revealed important aspects of immune recognition and generated strategies for synthetic mimicking of protein binding sites.Eur J Biochem. 1984 Nov 15;145(1):1-20. doi: 10.1111/j.1432-1033.1984.tb08516.x. Eur J Biochem. 1984. PMID: 6208027 Review.
Cited by
-
Boundary refinement of the lysozyme antigenic site around the disulphide bond 6-127 (site 1) by 'surface-simulation' synthesis.Biochem J. 1978 May 1;171(2):419-27. doi: 10.1042/bj1710419. Biochem J. 1978. PMID: 656053 Free PMC article.
-
Distance calculation of residues neighbouring to lysozyme antigenic sites. Site-neighbouring residues whose evolutionary substitution can modify the characteristics and binding energy of the sites.Biochem J. 1980 Apr 1;187(1):163-72. doi: 10.1042/bj1870163. Biochem J. 1980. PMID: 6157386 Free PMC article.
-
Immunochemical probes for food proteins after heat processing.Experientia. 1991 Jun 15;47(6):585-92. doi: 10.1007/BF01949882. Experientia. 1991. PMID: 2065756 Review.
-
Surface-simulation synthesis of the substrate-binding site of an enzyme. Demonstration with trypsin.Biochem J. 1985 Mar 1;226(2):477-85. doi: 10.1042/bj2260477. Biochem J. 1985. PMID: 3994669 Free PMC article.
-
Binding with lysozyme of antibodies against surface-simulation peptides representing the lysozyme antigenic sites.Biochem J. 1982 Mar 1;201(3):669-72. doi: 10.1042/bj2010669. Biochem J. 1982. PMID: 7092817 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources