doi: 10.1007/BF01952559.
Acyl-kallikrein; a delivery system for the kinin-liberating enzyme
- PMID: 6562018
- DOI: 10.1007/BF01952559
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Acyl-kallikrein; a delivery system for the kinin-liberating enzyme
Experientia.
.
Abstract
Glandular kallikrein can be temporarily acylated at the active centre by 4-amidinophenyl benzoates. The time course of reactivation depends on the nature of the acyl group introduced. Benzoyl kallikrein was used as a delivery system for kallikrein in vivo. In rabbits, bolus injection of the acylated enzyme caused a long-lasting drop in blood pressure due to sustained kinin liberation.
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