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. 1978 Jun;5(6):483-7.
doi: 10.1111/j.1365-2125.1978.tb01661.x.

The application of HPLC to the determination of some 1,4 benzodiazepines and their metabolites in plasma

G G Skellern, J Meier, B I Knight, B Whiting

The application of HPLC to the determination of some 1,4 benzodiazepines and their metabolites in plasma

G G Skellern et al. Br J Clin Pharmacol. 1978 Jun.

Abstract

1 A high pressure liquid chromatographic (HPLC) assay has been developed for the measurement of chlordiazepoxide and its metabolites, N-desmethylchlordiazepoxide and demoxepam in microgram concentrations in human plasma. 2 Another metabolite was detected in appreciable amounts in the plasma from patients receiving high doses of chlordiazepoxide after the first 3 days of treatment. 3 Preliminary studies would indicate that this metabolite is N-desmethyldiazepam. 4 A modified HPLC system, using a microparticulate column was developed to separate N-desmethyldiazepam from chlordiazepoxide and its other metabolites in plasma.

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References

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