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. 1978 May;37(5):776-9.
doi: 10.1038/bjc.1978.115.

Antigen shedding by human breast-cancer cells in vitro and in vivo

R E Nordquist, J H Anglin, M P Lerner
Free PMC article

Antigen shedding by human breast-cancer cells in vitro and in vivo

R E Nordquist et al. Br J Cancer. 1978 May.
Free PMC article

Abstract

Human breast cancer cells were adapted to chemically defined medium in order to recover naturally shed glycoproteins. Sephadex G-150 chromatography of these glycoproteins revealed 1 major and 2 minor peaks. When the cells were grown in the presence of 3H-leucine, the radioactive shed proteins had a Sephadex profile identical to the unlabelled shed glycoproteins. PAGE analysis of these proteins showed 5 major bands. Antigenically similar proteins were found in the serum of female nude mice bearing BOT-2 tumours, but not in controls.

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