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. 1984 May;25(5):666-8.
doi: 10.1128/AAC.25.5.666.

Cross-resistance between methicillin and cephalosporins for staphylococci: a general assumption not true for cefamandole

R F Frongillo, P Bianchi, A Moretti, M B Pasticci, S Ripa, S Pauluzzi

Cross-resistance between methicillin and cephalosporins for staphylococci: a general assumption not true for cefamandole

R F Frongillo et al. Antimicrob Agents Chemother. 1984 May.

Abstract

The antibacterial activity of cefamandole was evaluated against 120 methicillin-susceptible and methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococcal strains, using both large (10(8) CFU per ml) and small (10(4) CFU per ml) inocula. Cefamandole appeared superior to cephalothin against methicillin-resistant strains, displaying at 10 micrograms/ml a bacteriostatic and for some strains a bactericidal action against a large inoculum of bacteria.

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