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Case Reports
. 1984 Dec;58(3):724-30.

Functional deficiency of complement factor D in a monozygous twin

H C Kluin-Nelemans, H van Velzen-Blad, H P van Helden, M R Daha
Case Reports

Functional deficiency of complement factor D in a monozygous twin

H C Kluin-Nelemans et al. Clin Exp Immunol. 1984 Dec.

Abstract

An adult twin with recurrent bacterial infections was found to have a partial functional deficiency of complement factor D. Full restoration of alternative pathway activity and zymosan- or cobra venom factor-induced consumption of C3 and B was found after reconstitution of patient's serum with purified D. Family studies revealed normal D levels in the mother, a brother and another sister. After gel filtration of patient's sera only little D activity could be detected in the fractions, and trypsin activation of the fractions also did not uncover detectable precursor D activity.

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References

    1. Transplant Rev. 1976;32:93-120 - PubMed
    1. J Immunol. 1976 Jan;116(1):1-7 - PubMed
    1. Medicine (Baltimore). 1978 Jan;57(1):1-23 - PubMed
    1. Am J Med. 1980 Apr;68(4):549-58 - PubMed
    1. Rev Fr Transfus Immunohematol. 1979 Dec;22(5):587-614 - PubMed

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