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Comparative Study
. 1978 May;25(3):211-4.
doi: 10.1007/BF03004881.

Comparison of two benzodiazepines for anaesthesia induction: midazolam and diazepam

J G Reves, G Corssen, C Holcomb
Comparative Study

Comparison of two benzodiazepines for anaesthesia induction: midazolam and diazepam

J G Reves et al. Can Anaesth Soc J. 1978 May.

Abstract

Ro 21-3981 is a newly synthesized water soluble benzodiazepine derivative. Its pharmacological properties are similar to diazepam. This investigation was designed to establish the effective induction dosage of Ro 21-3981 and to compare it with diazepam for induction of anaesthesia. The ED50 for Ro 21-3981 induction is 0.15 mg/kg and ED 100 is 0.2 mg/kg. Ro 21-3981 is one and one-half times as potent as diazepam (0.3 mg/kg) and more rapid in action. There is significantly less pain on injection with Ro 21-3981 as compared to diazepam. Cardiovascular stability and apnoea were observed with both drugs. Ro 21-3981 is a promising anaesthetic induction drug that merits further human study.

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