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. 1983 Feb;46(2):85-8.
doi: 10.1007/BF00320663.

Influences of clotting factors (thrombin, factor XIII) and of fibronectin on the growth of tumor cells and leukemic cells in vitro

H D Bruhn, K H Zurborn

Influences of clotting factors (thrombin, factor XIII) and of fibronectin on the growth of tumor cells and leukemic cells in vitro

H D Bruhn et al. Blut. 1983 Feb.

Abstract

Thrombin, factor XIII and fibronectin were incubated with cultures of mouse sarcoma cells, human cervix carcinoma cells (HeLa cells) and cells of an acute lymphoblastic leukemia. Thrombin induced a significant increase of 3H-thymidine uptake into cells with a 1,5- to 2-fold increase of cell count. The cells of an acute lymphoblastic leukemia showed a similar response to the influence of thrombin. Factor XIII in tumor cells merely induced an increase of 3H-thymidine uptake, the cell count remained constant. The cells of an acute lymphoblastic leukemia showed under the influence of factor XIII a significant increase of cell count and thymidine uptake. HeLa cell growth was optimal at low fibronectin concentrations. Fibronectin concentrations of 1 mg/ml to 3 mg/ml inhibited HeLa and mouse sarcoma cell growth.

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References

    1. Proc Natl Acad Sci U S A. 1979 Nov;76(11):5731-5 - PubMed
    1. Klin Wochenschr. 1981 Feb 2;59(3):145-6 - PubMed
    1. Natl Cancer Inst Monogr. 1978 May;(48):157-65 - PubMed
    1. JAMA. 1980 Jul 11;244(2):179 - PubMed
    1. Int J Cancer. 1977 May 15;19(5):621-6 - PubMed