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. 1978 May;11(3):235-9.
doi: 10.1111/j.1365-2184.1978.tb00891.x.

G2 sub-population in mouse liver induced into mitosis by lead acetate

D D Choie, G W Richter

G2 sub-population in mouse liver induced into mitosis by lead acetate

D D Choie et al. Cell Tissue Kinet. 1978 May.

Abstract

A single intracardiac dose of lead acetate (40 microgram lead/g body weight) induced a 25-fold increase in mitosis of mouse hepatocytes 5 hr after injection, as determined by autoradiography. The prompt appearance of a mitotic wave and the relatively large number of mitoses suggest that the mitotic cells were derived from a hepatocyte sub-population arrested in the G2 phase. The injection of lead also stimulated a small increase in labeled hepatocytes within 6 hr. Analysis of grain counts gave no evidence for unscheduled DNA synthesis. The incremental labeled cells may have originated from a small fraction of the G1 population that was ready to enter the S phase without the usual pre-synthetic delay.

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