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. 1978 Mar;13(3):453-60.
doi: 10.1016/0092-8674(78)90319-7.

Evolution of a human Y chromosome-specific repeated sequence

H J Cooke, R D McKay

Evolution of a human Y chromosome-specific repeated sequence

H J Cooke et al. Cell. 1978 Mar.

Abstract

The structure and evolution of a repetitive sequence on the human Y chromosome has been studied by restriction enzyme analysis of both total DNA and the isolated sequence. The sequence is shown to cross-hybridize to sequences in female DNA forming unstable duplexes. Mouse/human cell hybrids have been used to investigate the pattern of sequence homology on the X chromosome and some autosomes. We conclude that this sequence is related to human satellite III, but shows considerable differences in structure.

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