Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983 Mar;80(6):1735-7.
doi: 10.1073/pnas.80.6.1735.

Prostaglandin D2, a cerebral sleep-inducing substance in rats

Prostaglandin D2, a cerebral sleep-inducing substance in rats

R Ueno et al. Proc Natl Acad Sci U S A. 1983 Mar.

Abstract

We continuously monitored the circadian sleep patterns of unrestrained rats for more than 96 hr and infused various prostaglandins into their third ventricles for 10 hr to study the effects on inducing sleep. Prostaglandin D2 at 6 fmol/min had no effect on either slow wave sleep or paradoxical sleep. However, prostaglandin D2 at as little as 60 fmol/min caused a significant amount of excess slow wave sleep as compared with the control level during saline infusion. Paradoxical sleep was induced by prostaglandin D2 at doses greater than 600 fmol/min. Prostaglandin D2 (600 fmol/min) increased slow wave sleep by 33% and paradoxical sleep by 56%. Although prostaglandin F2 alpha (600 fmol/min) increased the amount of slow wave sleep, its activity was less than that of the same amount of prostaglandin D2. Prostaglandin E2 (600 fmol/min) had no effect on increasing the amounts of both slow wave sleep and paradoxical sleep. During the infusion of prostaglandin D2, rats were easily aroused by clap sound stimulation and their sleeping and waking postures remained normal. Further, their sleep was episodic, as observed in the physiological sleep of rats.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Proc Natl Acad Sci U S A. 1982 Oct;79(19):6102-6 - PubMed
    1. J Biol Chem. 1980 Mar 10;255(5):1779-82 - PubMed
    1. Life Sci. 1982 Nov 8;31(19):2093-103 - PubMed
    1. Pharmacol Rev. 1974 Mar;26(1):33-67 - PubMed
    1. Proc Natl Acad Sci U S A. 1979 Dec;76(12):6231-4 - PubMed

Publication types