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. 1983 Mar;35(2):263-73.

Linkage between a marker locus and a quantitative trait of sibs

C C Cockerham, B S Weir

Linkage between a marker locus and a quantitative trait of sibs

C C Cockerham et al. Am J Hum Genet. 1983 Mar.

Abstract

Several variations of a method for detecting linkage between a marker locus and a quantitative trait in full sib families are presented along with computational details. All variations are based on contrasts within qualifying families of three or more sibs. The empirical powers of the various test statistics, evaluated by simulation, were very similar, and also similar to that of Smith. These single-generation tests are likely to be successful only for many families and relatively tight linkage.

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References

    1. Ann Hum Genet. 1980 Jan;43(3):249-54 - PubMed
    1. Ann Hum Genet. 1975 May;38(4):451-60 - PubMed

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