Prednisolone clearance: a possible determinant for glucocorticoid efficacy in patients with oral vesiculo-erosive diseases
- PMID: 6573375
- DOI: 10.1177/00220345830620051401
Prednisolone clearance: a possible determinant for glucocorticoid efficacy in patients with oral vesiculo-erosive diseases
Abstract
The pharmacokinetics of prednisolone were determined in 12 patients with oral vesiculo-erosive diseases. The bioavailability of prednisone in these patients exhibited a low intersubject variability, while the metabolic clearance rate of total and of unbound prednisolone varied considerably from patient to patient.
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