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. 1978 Jul;24(7):1131-3.

Hexosaminidase A in amniotic fluid of Tay-Sachs fetuses

B Geiger, R Navon, R Arnon
  • PMID: 657491

Hexosaminidase A in amniotic fluid of Tay-Sachs fetuses

B Geiger et al. Clin Chem. 1978 Jul.

Abstract

Hexosaminidase A is present in relatively low concentrations in cell-free amniotic fluids from pregnancies with Tay-Sachs fetuses. This isoenzyme was determined by an immunological procedure, radial immunodiffusion, by which hexosaminidase A can be directly and specifically detected, even in the presence of excess amounts of hexosaminidase B. No hexosaminidase A could be detected by the same procedure in Tay-Sachs fetal tissues, implying that this isoenzyme in the amniotic fluid originates from the mother.

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