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. 1983 Aug;49(4):593-7.

Investigation of porcine natural-killer cell activity with reference to African swine-fever virus infection

S G Norley, R C Wardley

Investigation of porcine natural-killer cell activity with reference to African swine-fever virus infection

S G Norley et al. Immunology. 1983 Aug.

Abstract

The natural killing of the human myeloid leukaemia cell line by pig mononuclear cells was investigated in an 18 hr assay; the most active natural-killer (NK) effectors were those cells not adhering to nylon-wool columns or rosetting with sheep red blood cells. Mononuclear cells cultured in the presence of African swine-fever virus maintained NK activity. Pigs infected with African swine-fever virus exhibited a suppressed NK activity, possibly due to the sensitivity of NK cells to increased temperatures. The possible role of NK cells in recovery from African swine fever is discussed.

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