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. 1983 Aug;80(16):5002-6.
doi: 10.1073/pnas.80.16.5002.

Two-dimensional electrophoresis of plasma polypeptides reveals "high" heterozygosity indices

B B Rosenblum, J V Neel, S M Hanash

Two-dimensional electrophoresis of plasma polypeptides reveals "high" heterozygosity indices

B B Rosenblum et al. Proc Natl Acad Sci U S A. 1983 Aug.

Abstract

A series of 62 plasma samples have been examined for genetic variation by the technique of two-dimensional polyacrylamide gel electrophoresis followed by silver-staining of the gels. Twenty polypeptides chosen without respect to variability were considered suitable for scoring. Of the total of 1,240 polypeptides, 29 could not be scored unambiguously. Seventy-five of the remaining 1,211 exhibited the combination of a normal and a variant polypeptide. All variants were present in either the father or the mother of the subject. This index of heterozygosity (6.2 +/- 0.7%) is substantially higher than those reported by others in similar studies of human fibroblasts, lymphocytes, kidney, or brain cells.

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References

    1. Clin Chem. 1982 Apr;28(4 Pt 2):979-86 - PubMed
    1. Clin Chem. 1982 Apr;28(4 Pt 2):969-78 - PubMed
    1. Hum Genet. 1982;62(2):142-7 - PubMed
    1. Hum Genet. 1982;62(2):148-51 - PubMed
    1. Proc Natl Acad Sci U S A. 1983 Feb;80(3):870-3 - PubMed

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