Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983 Oct 1;158(4):1350-5.
doi: 10.1084/jem.158.4.1350.

Treatment of (NZB x NZW)F1 disease with anti-I-A monoclonal antibodies

N E Adelman, D L Watling, H O McDevitt

Treatment of (NZB x NZW)F1 disease with anti-I-A monoclonal antibodies

N E Adelman et al. J Exp Med. .

Abstract

(NZB x NZW)F1 mice spontaneously develop an autoimmune syndrome characterized by a fatal immune complex glomerulonephritis. Administration of monoclonal antibodies specific for an I region gene product (I-Az) of the H-2 haplotype associated with susceptibility to glomerulonephritis in these animals produced a remission in female mice with established renal disease. The results demonstrated that anti-I-A therapy stabilized the level of proteinuria and increased the 1-yr survival rate from 10% to greater than 90% in treated animals relative to control mice. These findings may ultimately have therapeutic potential for the treatment of systemic lupus erythematosus.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Lancet. 1968 Mar 2;1(7540):440-1 - PubMed
    1. Blood. 1968 Sep;32(3):436-44 - PubMed
    1. Adv Immunol. 1968;9:215-66 - PubMed
    1. Arthritis Rheum. 1973 Mar-Apr;16(2):163-70 - PubMed
    1. J Lab Clin Med. 1973 Oct;82(4):619-33 - PubMed

Publication types

MeSH terms

Substances