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. 1983 Nov;35(6):1190-5.

Linkage analysis in dominant optic atrophy

J D Kivlin, E W Lovrien, D T Bishop, I H Maumenee

Linkage analysis in dominant optic atrophy

J D Kivlin et al. Am J Hum Genet. 1983 Nov.

Abstract

A kindred of German descent was studied for dominant optic atrophy, type Kjer (McKusick catalog no. 16540). One hundred twenty-three family members were examined clinically, and 36 affected, 81 normal, and six uncertain members were ascertained. Twenty-seven markers were analyzed for 121 members. The maximum lod score obtained was 2.0 at theta = .18 for linkage between the Kidd locus and dominant optic atrophy. Twenty-eight offspring were informative with 2-generation data. There was insufficient information for the acid phosphatase locus to aid gene localization. These data suggest that the locus for dominant optic atrophy is on chromosome 2.

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