[Effect of prostaglandins on the sensitivity of cerebral cortical neurons in rabbits to cholinoreceptor agonists]

Abstract

The effect of prostaglandins F2a and E2 on the reaction of rabbit's brain cortex neurons provoked by arecoline and nicotine (stimulators of M- and N-cholinereceptors) has been investigated by using a microionophoretic technique. As a rule, prostaglandin F2a decreased and prostaglandin E2 increased the effects of arecoline. Prostaglandins rarely changed the effect of nicotine. The data obtained confirms the supposition that prostaglandin F2a has inhibitory effects on the synthesis in neurons of the cyclical guanosinemonophosphate. Some hypothesis of the prostaglandins participation in integrative activity mechanisms of neurons are supposed.