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. 1978 May 17;13(2):129-31.
doi: 10.1007/BF00609757.

Placental transfer of chlorthalidone and its elimination in maternal milk

B A Mulley, G D Parr, W K Pau, R M Rye, J J Mould, N C Siddle

Placental transfer of chlorthalidone and its elimination in maternal milk

B A Mulley et al. Eur J Clin Pharmacol. .

Abstract

A gas chromatographic method has been used to determine chlorthalidone in amniotic fluid, maternal and foetal blood at delivery, and in maternal milk and blood three days after delivery, following the administration of chlorthalidone to nine pregnant women suffering from toxaemia of pregnancy. Placental transfer of chlorthalidone and elimination in maternal milk have been shown and the implications of these factors are discussed. An explanation has been proposed for our observations that foetal blood levels of the drug are about 15% of those in maternal blood.

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References

    1. Am J Obstet Gynecol. 1966 Oct 1;96(3):437-60 - PubMed
    1. Anal Chem. 1974 Jan;46(1):39-42 - PubMed
    1. JAMA. 1966 Feb 7;195(6):429-32 - PubMed
    1. Clin Pharmacol Ther. 1975 Apr;17(4):424-32 - PubMed
    1. Clin Pharmacol Ther. 1975 May;17(5):564-72 - PubMed

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