doi: 10.1016/0014-2999(78)90105-x.
3H-Apomorphine interactions with dopamine receptors in calf brain
- PMID: 658143
- DOI: 10.1016/0014-2999(78)90105-x
Item in Clipboard
3H-Apomorphine interactions with dopamine receptors in calf brain
Eur J Pharmacol.
.
Abstract
3H-apomorphine binds to membranes from areas of the corpus striatum and limbic system of calf brain saturable and with a drug specificity indicating that it labels dopamine receptors. In terms of drug specificity, log-logit displacement curve slopes and number of binding sites, 3H-apomorphine interacts with receptors in a manner more like 3H-dopamine than 3H-haloperidol. These properties of 3H-apomorphine binding are those of an apparently "pure" agonist in contrast to the partial agonist effects of apomorphine upon the dopamine-sensitive adenylate cyclase.
Similar articles
-
Dopamine receptors in human and calf brains, using [3H]apomorphine and an antipsychotic drug.Proc Natl Acad Sci U S A. 1976 Dec;73(12):4354-8. doi: 10.1073/pnas.73.12.4354. Proc Natl Acad Sci U S A. 1976. PMID: 12505 Free PMC article.
-
Species variation in dopamine receptor binding.Eur J Pharmacol. 1979 Nov 23;60(1):55-66. doi: 10.1016/0014-2999(79)90052-9. Eur J Pharmacol. 1979. PMID: 520417
-
Similar binding of 3H-ADTN and 3H-apomorphine to calf brain dopamine receptors.Eur J Pharmacol. 1979 Apr 15;55(2):137-42. doi: 10.1016/0014-2999(79)90385-6. Eur J Pharmacol. 1979. PMID: 456412
-
Dopamine receptors in the central nervous system.Fed Proc. 1978 Feb;37(2):131-6. Fed Proc. 1978. PMID: 414936 Review.
-
Brain receptors for dopamine and neuroleptics.Adv Biochem Psychopharmacol. 1978;19:167-76. Adv Biochem Psychopharmacol. 1978. PMID: 29446 Review. No abstract available.
Cited by
-
Differential sensitivity to acute administration of Ritalin, apomorphine, SCH 23390, but not raclopride in mice selectively bred for hyperactive wheel-running behavior.Psychopharmacology (Berl). 2003 May;167(3):242-50. doi: 10.1007/s00213-003-1399-9. Epub 2003 Apr 1. Psychopharmacology (Berl). 2003. PMID: 12669177
-
A review of the discovery, pharmacological characterization, and behavioral effects of the dopamine D2-like receptor antagonist eticlopride.CNS Neurosci Ther. 2008 Fall;14(3):248-62. doi: 10.1111/j.1755-5949.2008.00047.x. CNS Neurosci Ther. 2008. PMID: 18801115 Free PMC article. Review.
-
Dopamine receptor mediated inhibition by pergolide of electrically-evoked 3H-dopamine release from striatal slices of cat and rat: slight effect of ascorbate.Naunyn Schmiedebergs Arch Pharmacol. 1981 Aug;317(1):31-5. doi: 10.1007/BF00506253. Naunyn Schmiedebergs Arch Pharmacol. 1981. PMID: 7279007
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
