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. 1978 May 15;34(5):641-3.
doi: 10.1007/BF01937009.

Effect of variations in temperature on antimuscarinic activity in guinea-pig atria

C K Li, F Mitchelson

Effect of variations in temperature on antimuscarinic activity in guinea-pig atria

C K Li et al. Experientia. .

Abstract

The characteristics of the antimuscarinic activity of homatropine, gallamine and stercuronium in guinea-pig atria remained constant over the temperature range 22--37 degrees C in that a linear Arunlakshana-Schild plot was obtained with homatropine and nonlinear plots occurred with gallamine or stercuronium. A trend towards higher dose-ratios with reduction in temperature was only significant for gallamine.

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