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Clinical Trial
. 1983 Dec:12 Suppl D:125-31.
doi: 10.1093/jac/12.suppl_d.125.

Safety and tolerance comparison of imipenem-cilastatin to cephalothin and cefazolin

G B Calandra, F M Ricci, C Wang, K R Brown
Clinical Trial

Safety and tolerance comparison of imipenem-cilastatin to cephalothin and cefazolin

G B Calandra et al. J Antimicrob Chemother. 1983 Dec.

Abstract

Imipenem-cilastatin was compared, in two multicentre clinical trials, with cefazolin or cephalothin, in their efficacy, safety, and tolerance. Safety and tolerance for imipenem-cilastatin was similar to that of these two cephalosporins. There were more transient liver function test changes in the imipenem-cilastatin group, but the frequency was similar to that for beta-lactams in general. There were similar numbers of cases of transient neutropenia in each group. Clinical side effects were few for the treatment groups and all drugs were well tolerated.

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