Cigarette smoke ventilation decreases thromboxane B2 metabolism in isolated rat lungs
- PMID: 6583713
- DOI: 10.1016/0262-1746(83)90034-3
Cigarette smoke ventilation decreases thromboxane B2 metabolism in isolated rat lungs
Abstract
3H-TxB2 was infused into the pulmonary circulation of isolated perfused rat lungs. The metabolites were analysed from the nonrecirculating perfusion effluent. When the lungs were ventilated with cigarette smoke the amount of unmetabolized TxB2 in the effluent was increased by 50%. The amount of the main metabolite was, however, not changed. The efflux of radioactivity from the lungs after a bolus injection of 3H-TxB2 was slower during cigarette smoke ventilation than during air ventilation. This suggests that cigarette smoke inhibits the enzymes metabolizing TxB2 rather than the pulmonary thromboxane uptake system.
Similar articles
-
Thromboxane B2 (TxB2) metabolism in rat isolated lung and its inhibition by drugs.Prostaglandins Leukot Med. 1983 Mar;10(3):221-9. doi: 10.1016/0262-1746(82)90079-8. Prostaglandins Leukot Med. 1983. PMID: 6573689
-
Pulmonary inactivation of 5-hydroxytryptamine is decreased during cigarette smoke ventilation of rat isolated lungs.Br J Pharmacol. 1982 Oct;77(2):245-8. doi: 10.1111/j.1476-5381.1982.tb09292.x. Br J Pharmacol. 1982. PMID: 7139186 Free PMC article.
-
The effects of cigarette smoke on the fate of arachidonic acid in rat and hamster lungs.Prostaglandins. 1983 Nov;26(5):681-8. doi: 10.1016/0090-6980(83)90053-9. Prostaglandins. 1983. PMID: 6422507
-
Effects of cigarette smoking on the function of metabolizing arachidonic acid and angiotensin I in the isolated perfused rat lungs.J Tongji Med Univ. 1992;12(4):201-4. doi: 10.1007/BF02887849. J Tongji Med Univ. 1992. PMID: 1289565
-
Effects of vasoactive intestinal polypeptide on antigen-induced bronchoconstriction and thromboxane release in guinea-pig lung.Br J Pharmacol. 1993 May;109(1):243-50. doi: 10.1111/j.1476-5381.1993.tb13560.x. Br J Pharmacol. 1993. PMID: 8495242 Free PMC article.