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. 1984 Jan;35(1):91-9.
doi: 10.1002/jlb.35.1.91.

Decreased fibronectin biosynthesis by human cord blood mononuclear phagocytes in vitro

J S Gerdes, S D Douglas, G B Kolski, M C Yoder, R A Polin

Decreased fibronectin biosynthesis by human cord blood mononuclear phagocytes in vitro

J S Gerdes et al. J Leukoc Biol. 1984 Jan.

Abstract

Cultured cord blood monocytes synthesize significantly less fibronectin than cultured monocyte-macrophages from adult peripheral blood. Biosynthesis of the second component of complement in vitro is similar for both cell systems. The monocyte-macrophages from neonates and adults have similar functional and morphologic properties in long-term cultures. The decreased monocyte-macrophage biosynthesis of fibronectin observed in vitro may be in part related to the reduced plasma fibronectin concentrations and reticuloendothelial system hypofunction which occur in newborn infants.

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