Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Mar;81(6):1809-12.
doi: 10.1073/pnas.81.6.1809.

Shared idiotopes among monoclonal antibodies specific for A/PR/8/34 (H1N1) and X-31(H3N2) influenza viruses

T Moran, Y C Liu, J L Schulman, C A Bona

Shared idiotopes among monoclonal antibodies specific for A/PR/8/34 (H1N1) and X-31(H3N2) influenza viruses

T Moran et al. Proc Natl Acad Sci U S A. 1984 Mar.

Abstract

A monoclonal antibody specific for the hemagglutinin (HA) of influenza A X-31 (H3N2) virus (X-31) was obtained during a fusion of spleen cells from a BALB/c mouse immunized with influenza A/PR/8/34 (H1N1) virus (PR8). This monoclonal antibody (Py206) shares crossreactive idiotopes expressed on several monoclonal antibodies specific for PR8 HA and X-31 HA as well as an individual idiotope shared with one monoclonal antibody specific for X-31 HA. The presence of shared idiotypy among antibodies of such diverse binding specificities may result from regulation by idiotype-specific T cells. In addition, the results suggest that, in contrast to the diversity of paratypes expressed, relatively few germ-line variable region genes may be used in the antibody response to influenza A virus antigens.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1971 Oct;68(10):2616-20 - PubMed
    1. FEBS Lett. 1973 May 1;31(3):348-54 - PubMed
    1. J Exp Med. 1983 Feb 1;157(2):687-704 - PubMed
    1. Virology. 1980 Apr 30;102(2):458-62 - PubMed
    1. J Exp Med. 1975 Jul 1;142(1):197-211 - PubMed

Publication types

Substances