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Comparative Study
. 1984 Mar;81(6):1902-5.
doi: 10.1073/pnas.81.6.1902.

Gastrin and cholecystokinin in pituitary neurons

Comparative Study

Gastrin and cholecystokinin in pituitary neurons

J F Rehfeld et al. Proc Natl Acad Sci U S A. 1984 Mar.

Abstract

Gastrins occur in the hypothalamo-hypophyseal neurons of all mammalian species examined. In addition, human, bovine, and murine hypothalamo-hypophyseal neurons contain the homologous cholecystokinins (CCKs). CCK also occurs in neurons innervating bovine melanotrophs. Although the concentration of gastrin is of the same magnitude (15-30 pmol/g) in all neural lobes, the concentration of CCK varies from undetectable in pig and cat to 1 nmol/g in the cow. The constant occurrence of neurohypophyseal gastrin suggests a role different from that of the species-dependent CCK.

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