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. 1984 Apr;49(4):459-64.
doi: 10.1038/bjc.1984.73.

Prostaglandins in human mammary cancer

D M Watson, R W Kelly, R A Hawkins, W R Miller
Free PMC article

Prostaglandins in human mammary cancer

D M Watson et al. Br J Cancer. 1984 Apr.
Free PMC article

Abstract

Prostaglandins E2 and F2 alpha (PGE2 and PGF2 alpha) were measured by Gas Liquid Chromatography-Mass Spectrometry (GLC-MS) in extracts of 100 human mammary carcinomas. All tumours contained measurable amounts of both prostaglandins but wide variations between individual tumours were observed. Values for PGE2 ranged from 7 to 762 ng g-1 tissue with a median of 100 ng g-1 tissue. Values for PGF2 alpha ranged from 3 to 475 ng g-1 tissue (median 60 ng g-1 tissue). There was a highly significant positive correlation between amounts of the 2 prostaglandins in individual tumours. Amounts of both PGE2 and PGF2 alpha were not significantly related to the menopausal status of the patients or the presence of oestrogen and progesterone receptors.

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