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. 1984;66(4):344-6.
doi: 10.1007/BF00287638.

Heterozygous female carriers of the marker-X-chromosome: IQ estimation and replication status of fra(X)(q)

J Paul, U Froster-Iskenius, W Moje, E Schwinger

Heterozygous female carriers of the marker-X-chromosome: IQ estimation and replication status of fra(X)(q)

J Paul et al. Hum Genet. 1984.

Abstract

The IQ levels of 18 female carriers with the marker X chromosome were evaluated, and cytogenetic studies after BrdU incorporation were performed. A highly significant correlation between mental capacity and replication pattern of the X chromosomes could be demonstrated. Heterozygous females with normal intelligence showed a clear tendency to carry the fragile site at the late replicating X chromosome, while other female carriers with lower intelligence or mental impairment expressed their fragile site mainly with the early replicating X chromosome. This observation could be interpreted as an expression of Lyonisation .

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References

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