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. 1984 Jun;81(11):3526-8.
doi: 10.1073/pnas.81.11.3526.

Evidence of extrachromosomal forms of hepatitis B viral DNA in a bone marrow culture obtained from a patient recently infected with hepatitis B virus

E Elfassi, J L Romet-Lemonne, M Essex, M Frances-McLane, W A Haseltine

Evidence of extrachromosomal forms of hepatitis B viral DNA in a bone marrow culture obtained from a patient recently infected with hepatitis B virus

E Elfassi et al. Proc Natl Acad Sci U S A. 1984 Jun.

Abstract

A cell culture that produces Dane-like particles was initiated from a bone marrow aspirate of an acute hepatitis B patient. By using Southern blot analysis and a recombinant hepatitis B virus (HBV) DNA plasmid probe, extrachromosomal forms of HBV DNA were detected. The two forms of HBV DNA migrate as a closed circular 2.2-kb form and an open circular 3.9-kb form. There was no evidence of HBV DNA integration into the host genome.

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