Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Jun;81(12):3670-4.
doi: 10.1073/pnas.81.12.3670.

Mechanism of activation of an N-ras oncogene of SW-1271 human lung carcinoma cells

Y Yuasa, R A Gol, A Chang, I M Chiu, E P Reddy, S R Tronick, S A Aaronson

Mechanism of activation of an N-ras oncogene of SW-1271 human lung carcinoma cells

Y Yuasa et al. Proc Natl Acad Sci U S A. 1984 Jun.

Abstract

An N-ras-related transforming gene was detected in the human lung carcinoma cell line SW-1271 and molecularly cloned. The lesion responsible for its acquisition of transforming activity was localized to a single nucleotide transition from A to G in codon 61 of the predicted protein. This lesion in the second exon results in the substitution of arginine for glutamine at this position. These findings, together with previous studies, indicate that the activation of ras oncogenes in human tumors is most commonly due to point mutations at one of two major "hot spots" in the ras coding sequence.

PubMed Disclaimer

References

    1. Nature. 1982 Dec 9;300(5892):539-42 - PubMed
    1. Nature. 1982 Nov 11;300(5888):149-52 - PubMed
    1. Proc Natl Acad Sci U S A. 1983 Jan;80(2):383-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1983 Apr;80(8):2112-6 - PubMed
    1. Nature. 1983 Jun 2-8;303(5916):396-400 - PubMed

Associated data