Complex segregation analysis of Gilles de la Tourette syndrome: further evidence for a major locus mode of transmission
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- PMCID: PMC1684450
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Complex segregation analysis of Gilles de la Tourette syndrome: further evidence for a major locus mode of transmission
Am J Hum Genet.
1984 May.
Abstract
A sample of 35 published pedigrees of Gilles de la Tourette syndrome is studied using complex segregation analysis with pointers. Results indicate the presence of a rare, semidominant, incompletely penetrant allele leading to affection. This result is consistent with that previously reported by Comings et al. on a larger, independent sample.
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