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. 1984 Oct;43(5):703-9.
doi: 10.1136/ard.43.5.703.

Characteristics of spontaneously proliferating mononuclear cells in rheumatoid arthritis

K Froebel, R Dickson, D Lewis, M K Jasani, R D Sturrock

Characteristics of spontaneously proliferating mononuclear cells in rheumatoid arthritis

K Froebel et al. Ann Rheum Dis. 1984 Oct.

Abstract

The phenomenon of increased spontaneous incorporation of 3H-thymidine (3H-TdR) into peripheral blood mononuclear cells in rheumatoid arthritis (RA) has been investigated. The activity was found to be short lived and affected less than 1% of cells. Using a Percoll density gradient we identified two populations of active cells. RA patients with active synovitis and increased 3H-TdR incorporation in the low density population of cells have higher overall 3H-TdR incorporation than normal controls and patients with inactive RA. The low density cell population is enriched for Ia+ cells. The data are consistent with raised spontaneous 3H-TdR incorporation being due to an in-vivo cell mediated immune response.

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